Myo-inositol and is present in significant concentrations in the fluids of the female genital tract. Myo-inositol has been studied extensively, showing the ability to modify hormonal profiles. This is demonstrated by the capacity to reduce plasma insulin levels, improve the glucose/insulin ratio, and positively impact other hormonal parameters. The effects contribute to the normalization of menstrual cycles and improvement in hormonal parameters, particularly in patients with polycystic ovary syndrome (PCOS).

Folic acid plays a role in normalizing the menstrual cycle. When combined with other B vitamins such as B6 and B12, it contributes to the reduction of homocysteine levels in the blood. Elevated levels of homocysteine (hyperhomocysteinemia) in the blood have been associated with PCOS. Studies suggest an inverse relationship between homocysteine levels and the presence of folic acid, as well as vitamins B6 and B12.

Melatonin serves as an antioxidant within the follicle, playing a protective role.

Patients with irregular menstrual cycles or PCOS often exhibit a deficiency in vitamin D3. This deficiency is correlated with the development of insulin resistance, menstrual cycle disorders, and PCOS.

In summary, these components—Myo-inositol, folic acid, B vitamins (B6 and B12), melatonin, and vitamin D3—contribute to hormonal regulation, insulin sensitivity, and antioxidant protection, potentially improving outcomes for individuals with conditions like PCOS and irregular menstrual cycles.